Cholestatic pruritus is a severe, non-histamine-related itching caused by liver bile buildup. Bile acid resins like cholestyramine are first-line, but newer drugs like maralixibat offer better tolerability and effectiveness. Learn what works, what doesn't, and what's coming next.
Colchicine can become deadly when taken with certain macrolide antibiotics like clarithromycin due to CYP3A4 and P-gp inhibition. Learn which antibiotics are safe, how toxicity develops, and what to do if you're at risk.
Genetic differences can make medications dangerous for some people and useless for others. Learn how specific gene variants like CYP2D6 and HLA-B*15:02 affect drug reactions-and what you can do about it.