Motilium (domperidone): what it does and when people use it

Ever felt sick after a meal or struggled with bloating and slow digestion? Motilium (active ingredient: domperidone) is a drug many doctors use to reduce nausea and help the stomach empty faster. It boosts stomach contractions and eases the feeling of fullness, so food moves along more smoothly. People also use it short-term for migraine nausea and sometimes off-label to help with breast milk supply — but that last use needs a doctor’s supervision.

How to use Motilium safely

Typical adult dosing is 10 mg taken up to three times a day, usually 15–30 minutes before meals. Follow your doctor’s directions. Don’t exceed the prescribed dose or combine it with other medicines without checking. Motilium is meant for short-term relief of symptoms; if nausea or vomiting continue beyond a few days, see your clinician.

Not all countries approve domperidone the same way. Some regulators restrict its use because of rare heart risks, so doctors often weigh benefits and risks before prescribing. If you live in the US, note domperidone is not approved for general use there and might only be available through special programs.

Side effects, interactions, and who should avoid it

Most people tolerate Motilium well, but watch for dry mouth, abdominal cramps, or mild headache. More serious but rare problems include irregular heartbeat and sudden fainting. Risks rise if you take other drugs that prolong the QT interval or strong CYP3A4 inhibitors like ketoconazole, erythromycin, or some HIV drugs. Tell your doctor about all medicines and supplements you take.

Avoid domperidone if you have a known heart rhythm disorder, severe liver disease, or low levels of potassium or magnesium. Older adults and anyone with existing heart disease need a careful check before starting this medicine.

Want alternatives? Metoclopramide works similarly but can cause more movement-related side effects. Ondansetron is great for chemotherapy or post-op nausea. For milder cases, ginger, small frequent meals, and avoiding strong-smelling foods often help. We have a deeper piece on safe Motilium alternatives if you want a direct comparison.

Buying Motilium online? Use only licensed pharmacies, keep your prescription, and avoid bargain sites that don’t ask for a doctor’s approval. If you’re unsure whether Motilium is right for you, ask your healthcare provider — quick checks like an ECG or a medicine review can make the choice safer and clearer.

If symptoms continue despite treatment, or if you notice palpitations, fainting, or severe dizziness after taking Motilium, stop the drug and see emergency care. Simple medicines can do a lot, but the right choice depends on your health history and other drugs you take.