medroxyprogesterone: Uses, side effects, and what to know
Medroxyprogesterone is a synthetic progestin used for birth control, hormone therapy, and some gynecologic problems. You’ll see it as Depo‑Provera (an injection) and Provera (oral pills). Knowing the main uses, common side effects, and safety tips helps you make smarter choices with your provider.
How it works: medroxyprogesterone mimics natural progesterone. It prevents ovulation, thins the uterine lining, and changes cervical mucus. Those effects stop pregnancy, reduce heavy bleeding, and help manage conditions like endometriosis.
Main uses
Contraception: Depo‑Provera is a 3‑month injection given by a clinician. It’s very effective if you get shots on time. For people who forget daily pills, it’s a solid option.
Menstrual and gynecologic issues: Doctors prescribe medroxyprogesterone for abnormal uterine bleeding, endometriosis pain, and to protect the uterus when estrogen therapy is used in menopause.
Other uses: In some cases it treats certain cancers or helps control symptoms of hormone-sensitive conditions. Your doctor will explain if it’s right for you.
Side effects and safety
Common side effects include weight changes, mood swings, irregular bleeding, and decreased bone density with long‑term Depo use. Most side effects settle after a few months, but bone loss can be persistent—talk to your clinician about risks if you plan injections for more than two years.
Serious reactions are rare but can include blood clots or liver problems. Smokers over 35 and people with a history of clotting disorders or liver disease need careful evaluation before using medroxyprogesterone.
Drug interactions matter. Certain anticonvulsants and antibiotics may lower effectiveness of hormonal therapies. Always list your meds to your prescriber and check before starting anything new.
Pregnancy and breastfeeding: Avoid medroxyprogesterone if you are pregnant. For breastfeeding, injections may be used but discuss timing with your doctor since small amounts pass into breast milk.
Practical tips for patients: Keep a vaccination and injection schedule if you use Depo‑Provera. Ask about bone density monitoring and calcium/vitamin D supplements. If you miss a scheduled shot, contact your clinic—pregnancy risk rises after the recommended window.
Buying and online pharmacy advice: Buy from licensed pharmacies only. Check for a visible pharmacy license, secure payment, and a contact phone number. Ask for a prescription; responsible sites require one. If price is an issue, discuss generic options or assistance programs with your provider.
Questions to ask your clinician: Is medroxyprogesterone the best option for my goals? How long should I use it? What side effects should prompt immediate care? Clear answers help you get safer care.
Fertility and planning: If you plan pregnancy after stopping Depo‑Provera, start planning early. Fertility can take 6–12 months to return for some people after the last shot. If quick return to fertility matters, consider other birth control options like IUDs or daily pills and discuss switching with your clinician.
Monitoring: Your provider may check weight, mood, and bone health during long use. Keep a symptom diary and report sudden leg pain, chest pain, or shortness of breath right away—those could signal blood clots. Immediately.
