If you’ve started donepezil for memory problems, you might notice a queasy stomach in the first few weeks. That’s a common side effect, not a sign that the drug is failing. Donepezil works by boosting acetylcholine, a brain chemical that also speeds up gut activity. The extra gut movement can make you feel sick, especially if you take the pill on an empty stomach.
First, take your dose with food. A small snack—like toast, crackers, or a piece of fruit—creates a buffer that softens the stomach’s reaction. If you’re already eating a big breakfast, you can shift the dose to after lunch; many people find the midday timing gentler.
Second, stay hydrated but avoid gulping large amounts of liquid right before the pill. Sip water throughout the day instead of finishing a large glass in one go. Dehydration can amplify nausea, so keep a water bottle close.
Third, split the dose if your doctor agrees. Some prescriptions allow you to take half the tablet in the morning and the other half later, giving your gut a slower exposure. Always check with your prescriber before changing how you take the medication.
Most nausea fades after the first two weeks. If it sticks around longer, gets worse, or comes with vomiting, dizziness, or a rapid heartbeat, it’s time to reach out. Those symptoms could mean the dose is too high or that another medication is interacting with donepezil.
Also, watch for signs of severe stomach irritation—like black stools or blood in vomit. Those are rare, but they require immediate medical attention.
Don’t hesitate to ask about anti‑nausea options. Over‑the‑counter remedies such as ginger tablets or dimenhydrinate can be safe, but your doctor should confirm they won’t clash with donepezil.
Finally, keep a short diary of when you take the pill, what you eat, and how you feel. Patterns often emerge, and the notes give your doctor a clear picture of what’s happening.
Donepezil is a valuable tool for Alzheimer’s disease, and most people tolerate it well once the stomach adjusts. By timing the dose with food, staying hydrated, and monitoring your body’s response, you can keep nausea manageable and stay on track with your treatment.
Actionable ways to reduce nausea from donepezil (Aricept): dosing, timing, food strategies, safe anti-nausea meds, when to switch drugs, and red flags to call the doctor.